Advances in Exosome-Based Therapy for Chronic Endometritis by Modulating the Immune Microenvironment

doi:10.12280/gjfckx.20240908

Abstract

Abstract:

Chronic endometritis (CE) is characterized by abnormal infiltration of CD138+ endometrial stromal plasma cells. This persistent inflammatory state can disrupt immune cell infiltration, cytokine expression, and endometrial decidualization, negatively impacting embryo implantation and attracting significant research interest. Exosomes, nano-sized vesicles mediating intercellular communication, have shown considerable promise in modulating the immune microenvironment. This review summarizes the progress of exosome-based therapies for CE, focusing on their mechanism of action in improving the endometrial microenvironment through immune modulation. This may guide the development of novel therapeutic strategies for CE.

Key words: Exosomes, Endometritis, Lymphocytes, Cellular microenvironment, Embryo implantation, Therapy

LI Heng-bing, YUAN Hai-ning, ZHANG Yun-jie, ZHANG Jiang-lin, GUO Zi-zhen, SUN Zhen-gao. Advances in Exosome-Based Therapy for Chronic Endometritis by Modulating the Immune Microenvironment[J]. Journal of International Obstetrics and Gynecology, 2025, 52(1): 72-78.

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