The Application of Ataxia Telangiectasia Mutated and Rad3-Related Protein in the Pathogenesis, Development and Treatment of Ovarian Cancer

doi:10.12280/gjfckx.20250141

Abstract

Abstract:

Ovarian cancer is a common gynecological malignant tumor, and its treatment faces the dual challenge of platinum resistance and poly (ADP-ribose) polymerase inhibitor (PARPi) resistance. Therefore, how to overcome its drug resistance has become a research hotspot. The drug resistance of ovarian cancer is closely related to the reverse mutation of key genes in the DNA damage response. Ataxia telangiectasia mutated and Rad3-related protein (ATR) is an important intracellular protein kinase in cells, plays a crucial role in multiple physiological processes such as cell cycle regulation and DNA damage repair. Studies have found that high expression of ATR promotes the survival of ovarian cancer cells and increases their tolerance to chemotherapeutic drugs. This article reviews the classic biological functions of ATR, explores the role of ATR in the occurrence and development of ovarian cancer, and introduces the therapeutic strategies for ovarian cancer targeting ATR, aiming to provide guidance for the individualized treatment of ovarian cancer and further improve the prognosis of ovarian cancer patients.

Key words: DNA damage, Ovarian neoplasms, Poly(ADP-ribose) polymerase inhibitors, Drug resistance, neoplasm, Therapy, Ataxia telangiectasia mutated and Rad3-related protein

FENG Xiao-yu, YAN Li-jun. The Application of Ataxia Telangiectasia Mutated and Rad3-Related Protein in the Pathogenesis, Development and Treatment of Ovarian Cancer[J]. Journal of International Obstetrics and Gynecology, 2025, 52(3): 331-336.

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