Abstract: Objective：To investigate the serum squamous cell carcinoma antigen（SCCAg） in the diagnosis of cervical carcinoma，efficacy was assessed in terms of value，and its relationship with clinical stage and histological differentiation. Methods：We selected from 2011 September to 2012 March in Tianjin Central Hospital of Gynecology Obstetrics，145 patients，all suspicious cervical cancer patients，diagnosed by histopathology and divided into group CIN（55 cases） and malignant group
（90 cases）. Using a chemiluminescence method for the detection of preoperative serum SCCAg concentration，combined with clinical data and histopathological diagnosis， using statistical analysis to evaluate the value of SCCAg in diagnosis of cervical cancer， and the clinical staging， histological differentiation degree of correlation， the preoperative and postoperative evaluation value of SCCAg detection in the evaluation of curative effect. Results：The serum SCCAg concentration between cervical intraepithelial neoplasia and cervical cancer having significant differences，is a good marker of squamous cell carcinoma of the cervix；after treatment，SCCAg levels decreased significantly after treatment，the difference was statistically significant（P=0.000）；according to FIGO stage，group discussion，with the progression of the disease， clinical staging of exacerbations， SCCAg higher， positive rate increased， the two have positive correlation；in suspicious cervical cancer， detection sensitivity of SCCAg is 71.1%，specificity is 72.7%，accuracy is 71.7%，and negative predictive value is 60.6%，positive predictive value is 81.0%；CIN Ⅲ positive rate was 27.3%，in stage I patients testing positive for squamous cell carcinoma of the cervix rate is 66.7%. Conclusions：Squamous cell carcinoma antigen in squamous cell carcinoma of the cervix has diagnostic value on curative effect monitoring and prognosis，also has important clinical significance in early diagnosis，but still have limitations，relation with cervical pathological types，clinical stage，and is unconcerned with tissue differentiation degree.

Key words: Carcinoma, squamous cell, Antigens, neoplasm, Uterine cervical neoplasms, Cervical intraepithelial neoplasia