Abstract: HPV16 virus is the most correlative HPV type to cervical cancer and Encoding E5 protein. HPV16 E5 protein as one of membrane integration of proteins，mainly distributed in the golgi apparatus and endoplasmic reticulum. Numerous studies have demonstrated that HPV16 E5 protein regulates cervical cancer cell proliferation and invasion by promoting the activity of the epidermal growth factor receptor signal transduction pathway and COX -2 pathway，increasing the host cell immune evasion ,regulating the cell cycle，promoting cell transformation and reducing cell apoptosis. This paper summarized the research progress of the relationship between the HPV16 E5 protein of molecular biology and invasion of cervical cancer proliferation.

Key words: Human papillomavirus 16, Uterine cervical neoplasms, Cell proliferation, Apoptosis, E5 genes