Abstract: Objective：To explore the effect of OGG1 gene on the repair Schizandrin B（Sch B） prevent Benzo[a]pyrene（BaP） induced DNA oxidative stress in HTR8-SVneo cells. Methods：BaP damage HTR8-SV neo cells for oxidative stress damage model，the cells were divided into blank group，20 μmol/L BaP group，and Sch B（0.1，0.5，2.0 μmol/L） groups to detect cellular ROS，cellular 8-OHdG，the levels of cellular OGG1 mRNA and OGG1 protein. Results：Compared with blank group， the levels of OGG1 mRNA and OGG1 protein in BaP group were reduced（P＜0.05），but the levels of ROS and 8-OHdG were increased（P＜0.05）. Compared with of BaP group，the levels of OGG1 mRNA and OGG1 protein were increased in Sch B groups（P＜0.05），but the levels of ROS and 8-OHdG were reduced（P＜0.05）. Conclusions：Sch B can protect HTR8-SVneo cells DNA from BaP oxidatie stress injuries. The antioxidant activity may change with OGG1 gene expression levels，which affects the repair of DNA in the cell.

Key words: Benzo（a）pyrene, Schisandra chinensis, DNA glycosylases, Deoxyguanosine