Abstract: Metabonomics is a new scientific discipline developing in the 1990s, qualitative and quantitative analysis are carried out to analyze all the low molecular weight metabolites in an organism or cell, metabonome changes can reflect the patho-physiologic changes of an organism under a certain time and a certain condition. Ovarian cancer，cervical cancer and endometrial cancer are three major gynecologic malignant tumor，they have high mortality rate，high recurrence rate，low survival rate，long course and so on，their metabolites are different in the early stage and different clinical stages of disease, detected by the metabonomics method is conducive to deeply realize the occurrence and development of malignant tumor，early diagnosis of the disease, analyzing the metabolites produced during treatment is helpful for individual treatment of tumor，metabonomics can also be used in drug efficacy evaluation, which is benefit for discovering new antitumor drugs.

Key words: Metabolism, Genital neoplasms, female, Early diagnosis, Therapy