Abstract: 【Abstract】  Hydrops fetalis, classified into either immune or non-immune hydrops, is a pathological condition in which there is an excess of total body fluid, primarily within the fetal interstitial spaces or body cavities, its etiology and pathological and physiological mechanism is complex, the overall prognosis is poorer. At present, the diagnosis of hydrops fetalis mainly rely on the system of ultrasonic inspection, after which the etiology should be cleared, the clinical treatment mainly depends on the specific cause. In recent years, the further report of genetics research and development of the noninvasive prenatal diagnosis technology have deeply analyzed the etiology of hydrops fetalis. Reviewing the latest research reports about the pathological and physiological mechanism, causes, diagnosis with hydrops fetalis, for which providing reliable basis for early clinical intervention, so as to achieve early recognition, early diagnosis and early treatment.

Key words:  Hydrops fetalis, Genetics, Prenatal diagnosis, Therapy