Abstract: Uterine fibroids are the most common benign tumors in female reproductive organs. They are called intravascular leiomyomatosis when they grow into the veins or lymphatic vessels. The menstrual volume can be increased and the menstrual period is prolonged. The excessive tumor compression can cause swelling of the lower limbs. Abdominal discomfort, abdominal pain, difficult breathing, palpitations, chest pain, chest tightness, syncope and other symptoms can occur when the major arteries or veins are involved, there may even be sudden major bleeding and shock. This article described a case of a 49-year-old female patient with uterine leiomyomas growing to the right heart chamber leading to edema of the lower extremities for 3 years, chest tightness and chest pain for 2 months. The total hysterectomy + bilateral oophorosalpingectomy + pelvic mass resection was performed. The mass in the right atrium, right ventricle, pulmonary artery was removal and atrial septal defect was repaired. The pathological findings were uterine leiomyoma and intravascular leiomyoma. After 8 months of follow-up, the tumor did not recur. Uterine leiomyomatosis invading blood vessels into the right atrial and reaching the pulmonary artery is rare. The condition is serious, early detection, early diagnosis and early treatment is particularly important.

Key words: Leiomyomatosis, Leiomyoma, Uterus, Case reports