Abstract: Pre-eclampsia (PE) is a polygenic and multi-system damaging disease unique to the second and third trimester of pregnancy. If the disease progresses severely, it can lead to complications such as placental abruption, diffuse intravascular coagulation (DIC), eclampsia, and HELLP syndrome. It is the main cause of rising maternal and neonatal morbidity and mortality worldwide. Due to the dynamic progress of PE, and the clinical manifestations are diversified, the principle of treatment is mainly antispasmodic, antihypertensive, sedative and so on. The timely termination of pregnancy is the most effective clinical treatment. At present, studies on its etiology are still controversial. Most studies show that vascular endothelial function damage caused by immune and hormone response during pregnancy is the main pathophysiological change of PE. Among them, the inflammatory cascade caused by neutrophil activation plays an important role in the occurrence and development of PE. This article reviews the research progress on the role of neutrophil activation in vascular endothelial function damage in the pathogenesis of PE.

Key words: Pre-eclampsia;, Neutrophils;, Vascular endothelial function damage；, Endothelium, vascular