Research Progress on the Relationship between DKK3, Wnt/β-Catenin Signaling Pathway and Cervical Cancer

doi:10.12280/gjfckx.20201169

Abstract

Abstract:

Cervical cancer is one of the malignant tumors in women, and the pathogenesis and related pathway molecules have been studied more and more deeply. Among them, the research on Wnt/β-catenin signaling pathway has attracted great attention. The Wnt/β-catenin signaling pathway involves a wide range of physiological and pathological processes, including cell growth, differentiation, ontogeny, migration, genetic stability, apoptosis, stem cell self-renewal, and maintenance of adult tissue homeostasis. Stable β-catenin is accumulated in the cytoplasm and transferred to the nucleus, which activates the Wnt/β-catenin signaling pathway and is one of the inducing factors of multiple cancers. The accumulation of β-catenin occupies a core position in the Wnt/β-catenin signaling pathway. β-catenin drives target genes through Wnt/β-catenin signaling pathway and participates in the multi-step occurrence and development of cervical cancer. DKK3 may inhibit the Wnt/β-catenin signaling pathway by degrading β-catenin, blocking the nuclear transport of β-catenin, and thus become a potential key role in the inhibition of cervical cancer. Therefore, it is particularly important to study the relationship between DKK3, Wnt/β-catenin signaling pathway and cervical cancer.

Key words: Uterine cervical neoplasms, Dickkopf-3, Beta catenin, Wnt signaling pathway, Genes,tumor suppressor

WANG Ling, WANG Zhi-lian. Research Progress on the Relationship between DKK3, Wnt/β-Catenin Signaling Pathway and Cervical Cancer[J]. Journal of International Obstetrics and Gynecology, 2021, 48(5): 539-542.

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