Abstract:

Double primary breast and ovarian cancer (DPBOC) is a common type of multiple primary malignant neoplasms of the female reproductive system. Both breast and ovary are sex hormone regulating organs, and they have similar endocrine regulating mechanism. Because breast cancer is diagnosed early and has a good prognosis, the risk of primary ovarian cancer is higher than in the general women population. Studies on sporadic breast cancer or ovarian cancer have been relatively mature. However, the pathogenesis of DPBOC is still unclear. Due to the lack of sensitive and specific screening methods, it is difficult to differentiate from metastatic tumors, which has attracted little attention from clinicians. This review will focus on the pathogenesis, differential diagnosis of ovarian metastasis from breast cancer, treatment and prevention of DPBOC. The study may make clinicians pay attention to the early monitoring of the second primary carcinoma organ, take necessary preventive measures for high-risk groups, seize the best treatment opportunity, and prolong the survival time of patients with DPBOC as long as possible.

Key words: Breast neoplasms, Ovarian neoplasms, Neoplasms,multiple primary, Early diagnosis, Diagnosis,differential, Therapy, Double primary breast and ovarian cancer