Research Progress of NLRP3 Inflammasome/IL-1β Signaling Pathway in Endometriosis

doi:10.12280/gjfckx.20210484

Abstract

Abstract:

Endometriosis(EMs) often occurs in women of reproductive age, histologically characterized by the presence of glands and stroma of endometrial tissue outside the uterus. The main clinical manifestations are pain (dysmenorrhea, dyspareunia, chronic pelvic pain, dysuria, etc.) and infertility. Currently, the pathogenesis of EMs is still undefined, in which inflammation is believed to be the main pathophysiological process. NOD-like receptor family, pyrin domain containing protein 3(NLRP3) takes part in the assembly of the inflammasome which is an important role of the innate immune system. Recently, studies have shown that the activation of NLRP3 inflammasome is involved in the occurrence and development of EMs, thus elevating the level of interleukin 1β (IL-1β) and enhancing the adhesion, proliferation, differentiation and invasion of ectopic endometrial cells. In this paper, the research progress of NLRP3 inflammasome/IL-1β signaling pathway in EMs was reviewed in order to provide new strategies for the diagnosis and treatment of EMs.

Key words: Endometriosis, NLR family,pyrin domain-containing 3 protein, Inflammasomes, Inflammation, Interleukin-1beta

WANG Shi-yao, SUN Yun. Research Progress of NLRP3 Inflammasome/IL-1β Signaling Pathway in Endometriosis[J]. Journal of International Obstetrics and Gynecology, 2021, 48(6): 691-695.

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