Research Progress of Ferroptosis in Endometriosis

doi:10.12280/gjfckx.20220451

Abstract

Abstract:

Endometriosis as a common gynecological benign disease, however, has malignant behaviors such as invasion, infiltration, and distant metastasis. Ferroptosis is a newly discovered form of programmed cell death mainly characterized by the excessive intracellular free Fe²⁺ that mediates the Fenton reaction to produce hydroxyl radicals, inhibition of the intracellular antioxidant enzyme glutathione peroxidase 4, and peroxidation of cell membrane lipids leading to cell death. Endometriosis lesions exhibit ferroptosis resistance, a feature that impairs ectopic endometrial clearance and promotes their proliferation and migration. And part of the cells in turn promotes angiogenesis through ferroptosis. Sperm and oocyte damage as well as embryotoxicity from ferroptosis contribute further to endometriosis related infertility.

Key words: Endometriosis, Oxidative stress, Iron overload, Infertility, female, Ferroptosis

PENG Pei-xuan, WANG Li. Research Progress of Ferroptosis in Endometriosis[J]. Journal of International Obstetrics and Gynecology, 2022, 49(5): 481-485.

References 31

[1]	Koninckx PR, Ussia A, Adamyan L, et al. Pathogenesis of endometriosis: the genetic/epigenetic theory[J]. Fertil Steril, 2019, 111(2):327-340. doi: 10.1016/j.fertnstert.2018.10.013. doi: 10.1016/j.fertnstert.2018.10.013
[2]	Signorile PG, Viceconte R, Baldi A. New Insights in Pathogenesis of Endometriosis[J]. Front Med(Lausanne), 2022, 9:879015. doi: 10.3389/ fmed.2022.879015. doi: 10.3389/ fmed.2022.879015
[3]	Li B, Duan H, Wang S, et al. Ferroptosis resistance mechanisms in endometriosis for diagnostic model establishment[J]. Reprod Biomed Online, 2021, 43(1):127-138. doi: 10.1016/j.rbmo.2021.04.002. doi: 10.1016/j.rbmo.2021.04.002 pmid: 33992553
[4]	Mishima E, Conrad M. Nutritional and Metabolic Control of Ferroptosis[J]. Annu Rev Nutr, 2022, 42:275-309. doi: 10.1146/annurev-nutr-062320-114541. doi: 10.1146/annurev-nutr-062320-114541 pmid: 35650671
[5]	Alvarado-Díaz CP, Núñez MT, Devoto L, et al. Endometrial expression and in vitro modulation of the iron transporter divalent metal transporter-1: implications for endometriosis[J]. Fertil Steril, 2016, 106(2):393-401. doi: 10.1016/j.fertnstert.2016.04.002. doi: 10.1016/j.fertnstert.2016.04.002 pmid: 27117373
[6]	Imanaka S, Maruyama S, Kimura M, et al. Relationship between Cyst Fluid Concentrations of Iron and Severity of Dysmenorrhea in Patients with Ovarian Endometrioma[J]. Gynecol Obstet Invest, 2021, 86(1/2):185-192. doi: 10.1159/000514972. doi: 10.1159/000514972
[7]	Nanda A, K T, Banerjee P, et al. Cytokines, Angiogenesis, and Extracellular Matrix Degradation are Augmented by Oxidative Stress in Endometriosis[J]. Ann Lab Med, 2020, 40(5):390-397. doi: 10.3343/alm.2020.40.5.390. doi: 10.3343/alm.2020.40.5.390 pmid: 32311852
[8]	Amreen S, Kumar P, Gupta P, et al. Evaluation of Oxidative Stress and Severity of Endometriosis[J]. J Hum Reprod Sci, 2019, 12(1):40-46. doi: 10.4103/jhrs.JHRS_27_17. doi: 10.4103/jhrs.JHRS_27_17 pmid: 31007466
[9]	Woo JH, Choi YS, Choi JH. Iron-Storage Protein Ferritin Is Upregulated in Endometriosis and Iron Overload Contributes to a Migratory Phenotype[J]. Biomedicines, 2020, 8(11):454. doi: 10.3390/biomedicines8110454. doi: 10.3390/biomedicines8110454
[10]	Shigetomi H, Imanaka S, Kobayashi H. Effects of iron-related compounds and bilirubin on redox homeostasis in endometriosis and its malignant transformations[J]. Horm Mol Biol Clin Investig,2021 Dec 2. doi: 10.1515/hmbci-2021-0065. Epub ahead of print. doi: 10.1515/hmbci-2021-0065
[11]	Ramírez-Pavez TN, Martínez-Esparza M, Ruiz-Alcaraz AJ, et al. The Role of Peritoneal Macrophages in Endometriosis[J]. Int J Mol Sci, 2021, 22(19):10792. doi: 10.3390/ijms221910792. doi: 10.3390/ijms221910792
[12]	Wan Y, Gu C, Kong J, et al. Long noncoding RNA ADAMTS9-AS1 represses ferroptosis of endometrial stromal cells by regulating the miR-6516-5p/GPX4 axis in endometriosis[J]. Sci Rep, 2022, 12(1):2618. doi: 10.1038/s41598-022-04963-z. doi: 10.1038/s41598-022-04963-z pmid: 35173188
[13]	Wan Y, Song Y, Chen J, et al. Upregulated Fibulin-1 Increased Endometrial Stromal Cell Viability and Migration by Repressing EFEMP1-Dependent Ferroptosis in Endometriosis[J]. Biomed Res Int, 2022, 2022:4809415. doi: 10.1155/2022/4809415. doi: 10.1155/2022/4809415
[14]	Srivastava SR, Zadafiya P, Mahalakshmi R. Hydrophobic Mismatch Modulates Stability and Plasticity of Human Mitochondrial VDAC2[J]. Biophys J, 2018, 115(12):2386-2394. doi: 10.1016/j.bpj.2018.11.001. doi: S0006-3495(18)31220-7 pmid: 30503532
[15]	Liang Z, Wu Q, Wang H, et al. Silencing of lncRNA MALAT1 facilitates erastin-induced ferroptosis in endometriosis through miR-145-5p/MUC1 signaling[J]. Cell Death Discov, 2022, 8(1):190. doi: 10.1038/s41420-022-00975-w. doi: 10.1038/s41420-022-00975-w
[16]	Ng SW, Norwitz SG, Taylor HS, et al. Endometriosis: The Role of Iron Overload and Ferroptosis[J]. Reprod Sci, 2020, 27(7):1383-1390. doi: 10.1007/s43032-020-00164-z. doi: 10.1007/s43032-020-00164-z
[17]	Sokalska A, Hawkins AB, Yamaguchi T, et al. Lipophilic statins inhibit growth and reduce invasiveness of human endometrial stromal cells[J]. J Assist Reprod Genet, 2019, 36(3):535-541. doi: 10.1007/s10815-018-1352-9. doi: 10.1007/s10815-018-1352-9
[18]	Almassinokiani F, Mehdizadeh A, Sariri E, et al. Effects of simvastatin in prevention of pain recurrences after surgery for endometriosis[J]. Med Sci Monit, 2013, 19:534-539. doi: 10.12659/MSM.883967. doi: 10.12659/MSM.883967
[19]	Mori M, Ito F, Shi L, et al. Ovarian endometriosis-associated stromal cells reveal persistently high affinity for iron[J]. Redox Biol, 2015, 6:578-586. doi: 10.1016/j.redox.2015.10.001. doi: S2213-2317(15)00152-4 pmid: 26498255
[20]	Zhou Y, Zhao X, Zhang L, et al. Iron overload inhibits cell proliferation and promotes autophagy via PARP1/SIRT1 signaling in endometriosis and adenomyosis[J]. Toxicology, 2022, 465:153050. doi: 10.1016/j.tox.2021.153050. doi: 10.1016/j.tox.2021.153050
[21]	Li G, Lin Y, Zhang Y, et al. Endometrial stromal cell ferroptosis promotes angiogenesis in endometriosis[J]. Cell Death Discov, 2022, 8(1):29. doi: 10.1038/s41420-022-00821-z. doi: 10.1038/s41420-022-00821-z pmid: 35039492
[22]	Li Y, Zeng X, Lu D, et al. Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis[J]. Hum Reprod, 2021, 36(4):951-964. doi: 10.1093/humrep/deaa363. doi: 10.1093/humrep/deaa363
[23]	Arumugam K. Endometriosis and infertility: raised iron concentration in the peritoneal fluid and its effect on the acrosome reaction[J]. Hum Reprod, 1994, 9(6):1153-1157. doi: 10.1093/oxfordjournals.humrep.a138649. doi: 10.1093/oxfordjournals.humrep.a138649 pmid: 7962392
[24]	Machado-Neves M. Effect of heavy metals on epididymal morphology and function: An integrative review[J]. Chemosphere, 2022, 291(Pt 2):133020. doi: 10.1016/j.chemosphere.2021.133020. doi: 10.1016/j.chemosphere.2021.133020
[25]	Cacciottola L, Donnez J, Dolmans MM. Oxidative stress, mitochondria, and infertility: Is the relationship fully established?[J]. Fertil Steril, 2021, 116(2):306-308. doi: 10.1016/j.fertnstert.2021.04.026. doi: 10.1016/j.fertnstert.2021.04.026 pmid: 34016431
[26]	Wang L, Tang J, Wang L, et al. Oxidative stress in oocyte aging and female reproduction[J]. J Cell Physiol, 2021, 236(12):7966-7983. doi: 10.1002/jcp.30468. doi: 10.1002/jcp.30468 pmid: 34121193
[27]	Li A, Ni Z, Zhang J, et al. Transferrin Insufficiency and Iron Overload in Follicular Fluid Contribute to Oocyte Dysmaturity in Infertile Women With Advanced Endometriosis[J]. Front Endocrinol(Lausanne), 2020, 11:391. doi: 10.3389/fendo.2020.00391. doi: 10.3389/fendo.2020.00391
[28]	Cacciottola L, Donnez J, Dolmans MM. Can Endometriosis-Related Oxidative Stress Pave the Way for New Treatment Targets?[J]. Int J Mol Sci, 2021, 22(13):7138. doi: 10.3390/ijms22137138. doi: 10.3390/ijms22137138
[29]	Chang LC, Chiang SK, Chen SE, et al. Heme oxygenase-1 mediates BAY 11-7085 induced ferroptosis[J]. Cancer Lett, 2018, 416:124-137. doi: 10.1016/j.canlet.2017.12.025. doi: 10.1016/j.canlet.2017.12.025
[30]	Li S, Zhou Y, Huang Q, et al. Iron overload in endometriosis peritoneal fluid induces early embryo ferroptosis mediated by HMOX1[J]. Cell Death Discov, 2021, 7(1):355. doi: 10.1038/s41420-021-00751-2. doi: 10.1038/s41420-021-00751-2 pmid: 34782602
[31]	Chen X, Zhou Y, Wu D, et al. Iron overload compromises preimplantation mouse embryo development[J]. Reprod Toxicol, 2021, 105:156-165. doi: 10.1016/j.reprotox.2021.08.010. doi: 10.1016/j.reprotox.2021.08.010 pmid: 34481919