Research Progress of Ferroptosis in Ovarian Cancer

doi:10.12280/gjfckx.20220884

Abstract

Abstract:

Ferroptosis is a novel cell death mode different from autophagy, apoptosis and necrosis, which is initiated by cellluar iron overload and lipid peroxidation. In recent years, an increasing number studies have explored the role of ferroptosis related mechanisms in ovarian cancer, and found that altered the metabolism of iron and lipid in ovarian cancer cells, as well as the expression of P53, Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) can regulate the ferroptosis of cancer cells, thereby delaying the progression of ovarian cancer. Studies also confirmed that ferroptosis can not only improve the sensitivity of ovarian cancer cells to platinum drugs, enhance the effect of chemotherapy, but also improve the resistance of ovarian cancer cells to poly (ADP-ribose) polymerase (PARP) inhibitors, and improve the clinical benefits of PARP inhibitor treatment in ovarian cancer patients, PARP inhibitor and immunotherapy can promote the ferroptosis of ovarian cancer cells in the treatment of ovarian cancer. This shows that ferroptosis and chemotherapy, PARP inhibitors and immunotherapy have synergistic effects in inhibiting the growth of ovarian cancer cells. Therefore, ferroptosis may become a new target for the treatment of ovarian cancer in the future.

Key words: Ferroptosis, Ovarian neoplasms, Chemotherapy, Drug tolerance, Poly (ADP-ribose) polymerase inhibitors, Immunotherapy

QI Qi, ZHANG Jing, WANG Min, LIN Zhi-ming, XU Fei-xue. Research Progress of Ferroptosis in Ovarian Cancer[J]. Journal of International Obstetrics and Gynecology, 2023, 50(2): 206-210.

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