The Relationship between Serum Vitamin Level during Pregnancy and Preeclampsia

doi:10.12280/gjfckx.20230681

Abstract

Abstract:

Preeclampsia (PE) is one of the main causes of increased perinatal mortality, and its pathogenesis remains unclear. The present study has found that the levels of multivitamins during pregnancy were correlated with incidence of PE. It has been proved that vitamin D is involved in placental formation, inflammatory reaction, oxidative stress and immune activation in the pathogenesis of PE. Vitamin D deficiency can lead to PE through the above mechanisms. In addition, the levels of vitamin E in patients with PE are lower than those in normal pregnant women, suggesting that the lack of vitamin E may increase the risk of PE, but the specific mechanism is still under investigation, it may be related to its antioxidant activity. The relationship between vitamin A levels and PE is controversial. PE is also associated with homocysteine, folic acid (vitamin B₉), vitamin B₁₂ and vitamin B₆, also known as carbon metabolism. The deficiency of related vitamins leads to homocysteine metabolism disorder, thus causing PE. Vitamin B₃ primarily protects against PE by preserving the endothelium and regulating redox reactions. Vitamin C deficiency is associated with PE, and the use of vitamin C during fluid replacement therapy can partially reduce the incidence of pulmonary edema.

Key words: Pre-eclampsia, Vitamins, Oxidative stress, Immunomodulation, Therapy

LI Jie-peng, CHENG Yao, LIU Ze-jun, YE Ming-zhu, SUN Guo-qiang. The Relationship between Serum Vitamin Level during Pregnancy and Preeclampsia[J]. Journal of International Obstetrics and Gynecology, 2024, 51(1): 5-9.

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