Abstract: Hot flash is the most common and special symptom of menopause and also is one of the most painful symptoms. However，the mechanisms responsible for the pathogenesis of the hot flash are not completely understood. Recently，some researchers found that hot flash could be associated with kinds of factors .Among all possible reasons, hypothalamic temperature set point becoming narrow are widely accepted by most scholars . In addition, the low level of estrogen leads high level noradrenalin and low level 5-hydroxytryptamine which will impact thermoregulation. And also hot flash could be bound with calcitonin gene-related peptide ,beta-endorphin and other social psychological factors. Now we will summarize the current studies in the mechanisms of the hot flash.

Key words: Tidal fever, Vasomotor system, Norepinephrine, Serotonin, Body temperature regulation, Calcitonin gene-related peptide