Clinical Effect of Xingnao Kaiqiao Acupuncture on Postpartum Depression

doi:10.12280/gjfckx.20230208

Abstract

Abstract:

Objective: To investigate the effect of Xingnao Kaiqiao acupuncture on postpartum depression (PPD). Methods: A total of 80 patients with PPD in our hospital were selected from January 2022 to September 2022 and divided into two groups with 40 cases in each group by random number method. The control group was given conventional Western medicine, and the observation group was treated with acupuncture combined with Western medicine. The course of treatment was eight weeks. The therapeutic efficacy and safety of the two groups were analyzed, and the degree of depression [Hamilton Depression Scale (HAMD), Edinburgh Postpartum Depression Scale (EPDS)], sex hormone levels [progesterone (P), estradiol (E₂)], neurotransmitter levels [5-hydroxytryptamine (5-HT), orphanin FQ (OFQ)] were compared between the two groups before treatment and eight weeks after treatment. Results: The efficacy of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). After eight weeks of treatment, the HAMD, EPDS scores and OFQ levels of the two groups decreased compared with those before treatment, and the observation group was lower than the control group; the P, E₂ and 5-HT levels of the two groups increased compared with those before treatment, and the observation group was higher than the control group, and the difference was statistically significant (P<0.05). Conclusions: Xingnao Kaiqiao acupuncture has a significant effect on the treatment of PPD, which can improve the expression of depressed-related factors and reduce the degree of depression with high safety.

Key words: Sertraline, Depressive disorder, Postpartum period, Serotonin, Xingnao Kaiqiao acupuncture therapy, Orphanin FQ

WANG Qiang-yu, ZHANG Hai-yan, XIE An-ni, LI Xin-hua. Clinical Effect of Xingnao Kaiqiao Acupuncture on Postpartum Depression[J]. Journal of International Obstetrics and Gynecology, 2023, 50(5): 555-558.

Figures/Tables 6

References 16

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组别	n	年龄（岁）	病程（周）	产妇类型		分娩方式		抑郁严重程度
组别	n	年龄（岁）	病程（周）	初产妇	经产妇	剖宫产	顺产	轻度	中度
观察组	40	31.13±4.56	11.28±4.04	26（65.00）	14（35.00）	25（62.50）	15（37.50）	21（52.50）	19（47.50）
对照组	40	32.55±5.12	12.77±4.51	30（75.00）	10（25.00）	29（72.50）	11（27.50）	26（65.00）	14（35.00）
t或χ²		1.315	1.545	0.952		0.912		1.289
P		0.192	0.126	0.329		0.340		0.256

组别	n	年龄（岁）	病程（周）	产妇类型		分娩方式		抑郁严重程度
组别	n	年龄（岁）	病程（周）	初产妇	经产妇	剖宫产	顺产	轻度	中度
观察组	40	31.13±4.56	11.28±4.04	26（65.00）	14（35.00）	25（62.50）	15（37.50）	21（52.50）	19（47.50）
对照组	40	32.55±5.12	12.77±4.51	30（75.00）	10（25.00）	29（72.50）	11（27.50）	26（65.00）	14（35.00）
t或χ²		1.315	1.545	0.952		0.912		1.289
P		0.192	0.126	0.329		0.340		0.256

组别	n	HAMD		EPDS
组别	n	治疗前	治疗8周后	治疗前	治疗8周后
对照组	40	20.38±2.22	13.13±1.22^a	17.53±2.00	12.79±1.76^a
观察组	40	21.16±2.24	8.33±0.66^a	18.55±2.61	8.24±1.23^a
t		1.557	21.870	1.971	13.397
P		0.124	<0.001	0.053	<0.001

组别	n	HAMD		EPDS
组别	n	治疗前	治疗8周后	治疗前	治疗8周后
对照组	40	20.38±2.22	13.13±1.22^a	17.53±2.00	12.79±1.76^a
观察组	40	21.16±2.24	8.33±0.66^a	18.55±2.61	8.24±1.23^a
t		1.557	21.870	1.971	13.397
P		0.124	<0.001	0.053	<0.001

组别	n	临床痊愈	显效	有效	无效	总有效率
观察组	40	19（47.50）	11（27.50）	7（17.50）	3（7.50）	37（92.50）
对照组	40	9（22.50）	7（17.50）	14（35.00）	10（25.00）	30（75.00）
χ²或Z		3.114				4.501
P		0.002				0.034