Research Progress on Antenatal Depression Causing Mental Disorders in Offspring

doi:10.12280/gjfckx.20241092

Abstract

Abstract:

Antenatal Depression is a prevalent psychological disorder during pregnancy, which not only increases the risk of other pregnancy complications and adverse outcomes but also increases the likelihood of mental disorders in offspring. In recent years, there have been studies on antenatal depression leading to mental disorders in offspring, and it has been found that antenatal depression is significantly associated with childhood depression, attention deficit hyperactivity disorder (ADHD), and autism spectrum disorder (ASD). However, the underlying mechanisms remain unclear. This paper provides a comprehensive review of the assessment and prediction of antenatal depression, and the common mental disorders in offspring resulting from antenatal depression, aiming to guide clinical practice and scientific research.

Key words: Pregnant women, Depressive disorder, Child, Attention deficit disorder with hyperactivity, Autism spectrum disorder, Childhood depression disorder

SU Yi-wen, SHI Zhong-hua. Research Progress on Antenatal Depression Causing Mental Disorders in Offspring[J]. Journal of International Obstetrics and Gynecology, 2025, 52(2): 132-136.

References 31

[1]	Woody CA, Ferrari AJ, Siskind DJ, et al. A systematic review and meta-regression of the prevalence and incidence of perinatal depression[J]. J Affect Disord, 2017, 219:86-92. doi: 10.1016/j.jad.2017.05.003.
[2]	Yin X, Sun N, Jiang N, et al. Prevalence and associated factors of antenatal depression: Systematic reviews and meta-analyses[J]. Clin Psychol Rev, 2021, 83:101932. doi: 10.1016/j.cpr.2020.101932.
[3]	肖霄, 朱社宁, 张旱愉, 等. 产前抑郁概念分析[J]. 护理学报, 2017, 24(19):18-23. doi: 10.16460/j.issn1008-9969.2017.19.018.
[4]	李建娟, 秦峰. 孕期抑郁情绪对妊娠并发症和围生结局的影响分析[J]. 保健医学研究与实践, 2023, 20(3):43-45. doi: 10.11986/j.issn.1673-873X.2023.03.011.
[5]	Miller ES, Saade GR, Simhan HN, et al. Trajectories of antenatal depression and adverse pregnancy outcomes[J]. Am J Obstet Gynecol, 2022, 226(1):108.e1-108.e9. doi: 10.1016/j.ajog.2021.07.007.
[6]	Wu J, Zhou F, Wang Y, et al. Associations between maternal early pregnancy depression and longitudinal fetal growth[J]. J Affect Disord, 2024, 362:808-815. doi: 10.1016/j.jad.2024.07.068.
[7]	Smith A, Twynstra J, Seabrook JA. Antenatal depression and offspring health outcomes[J]. Obstet Med, 2020, 13(2):55-61. doi: 10.1177/1753495X19843015.
[8]	张琳, 施春华. 母亲抑郁与儿童精神障碍的关系研究进展[J]. 教育生物学杂志, 2020, 8(4):270-277. doi: 10.3969/j.issn.2095-4301.2020.04.008.
[9]	Stefana A, Langfus JA, Palumbo G, et al. Comparing the factor structures and reliabilities of the EPDS and the PHQ-9 for screening antepartum and postpartum depression: a multigroup confirmatory factor analysis[J]. Arch Womens Ment Health, 2023, 26(5):659-668. doi: 10.1007/s00737-023-01337-w. pmid: 37464191
[10]	Li F, Cui Y, Li Y, et al. Prevalence of mental disorders in school children and adolescents in China: diagnostic data from detailed clinical assessments of 17, 524 individuals[J]. J Child Psychol Psychiatry, 2022, 63(1):34-46. doi: 10.1111/jcpp.13445.
[11]	Beck-Pancer D, Aghaee S, Swint A, et al. Maternal Depression and Antidepressant Use During Pregnancy and Associations with Depressive Symptoms and Suicidality in Adolescent Children[J]. Clin Epidemiol, 2023, 15:613-628. doi: 10.2147/CLEP.S380894. pmid: 37187769
[12]	Cattane N, Räikkönen K, Anniverno R, et al. Depression, obesity and their comorbidity during pregnancy: effects on the offspring′s mental and physical health[J]. Mol Psychiatry, 2021, 26(2):462-481. doi: 10.1038/s41380-020-0813-6.
[13]	Clayborne ZM, Gilman SE, Khandaker GM, et al. Associations between prenatal stress with offspring inflammation, depression and anxiety[J]. Psychoneuroendocrinology, 2024, 169:107162. doi: 10.1016/j.psyneuen.2024.107162.
[14]	Davis EP, Hankin BL, Glynn LM, et al. Prenatal Maternal Stress, Child Cortical Thickness, and Adolescent Depressive Symptoms[J]. Child Dev, 2020, 91(2):e432-e450. doi: 10.1111/cdev.13252.
[15]	Hay RE, Reynolds JE, Grohs MN, et al. Amygdala-Prefrontal Structural Connectivity Mediates the Relationship between Prenatal Depression and Behavior in Preschool Boys[J]. J Neurosci, 2020, 40(36):6969-6977. doi: 10.1523/JNEUROSCI.0481-20.2020. pmid: 32788182
[16]	Posner J, Polanczyk GV, Sonuga-Barke E. Attention-deficit hyperactivity disorder[J]. Lancet, 2020, 395(10222):450-462. doi: 10.1016/S0140-6736(19)33004-1. pmid: 31982036
[17]	杨晓蕾, 李洪杰, 多永胜, 等. 中国儿童青少年1990—2019年注意缺陷多动障碍疾病负担及预测[J]. 中国学校卫生, 2023, 44(7):1107-1111. doi: 10.16835/j.cnki.1000-9817.2023.07.034.
[18]	Ma SS, Zhu DM, Yin WJ, et al. The role of neonatal vitamin D in the association of prenatal depression with toddlers ADHD symptoms: A birth cohort study[J]. J Affect Disord, 2021, 281:390-396. doi: 10.1016/j.jad.2020.12.033.
[19]	Chen LM, Pokhvisneva I, Lahti-Pulkkinen M, et al. Independent Prediction of Child Psychiatric Symptoms by Maternal Mental Health and Child Polygenic Risk Scores[J]. J Am Acad Child Adolesc Psychiatry, 2024, 63(6):640-651. doi: 10.1016/j.jaac.2023.08.018.
[20]	Vizzini L, Popovic M, Zugna D, et al. Maternal anxiety, depression and sleep disorders before and during pregnancy, and preschool ADHD symptoms in the NINFEA birth cohort study[J]. Epidemiol Psychiatr Sci, 2019, 28(5):521-531. doi: 10.1017/S2045796018000185.
[21]	Bleker LS, van Dammen L, Leeflang M, et al. Hypothalamic-pituitary-adrenal axis and autonomic nervous system reactivity in children prenatally exposed to maternal depression: A systematic review of prospective studies[J]. Neurosci Biobehav Rev, 2020, 117:243-252. doi: 10.1016/j.neubiorev.2018.05.033. pmid: 30366609
[22]	Lautarescu A, Craig MC, Glover V. Prenatal stress: Effects on fetal and child brain development[J]. Int Rev Neurobiol, 2020, 150:17-40. doi: 10.1016/bs.irn.2019.11.002. pmid: 32204831
[23]	Li C, He WQ. Prevalence and treatment of autism spectrum disorder in the United States, 2016-2022[J]. Autism Res, 2024, 17(9):1916-1927. doi: 10.1002/aur.3228. pmid: 39221608
[24]	Genovese A, Butler MG. Clinical Assessment, Genetics, and Treatment Approaches in Autism Spectrum Disorder (ASD)[J]. Int J Mol Sci, 2020, 21(13):4726. doi: 10.3390/ijms21134726.
[25]	Di Gesù CM, Buffington SA. The early life exposome and autism risk: a role for the maternal microbiome?[J]. Gut Microbes, 2024, 16(1):2385117. doi: 10.1080/19490976.2024.2385117.
[26]	Kaplan ZB, Schmidt RJ. Parental psychiatric diagnoses as predictive factors for autism spectrum disorder in the child: confluence of genetics and environment[J]. Lancet Reg Health Eur, 2024, 40:100919. doi: 10.1016/j.lanepe.2024.100919.
[27]	Avalos LA, Chandran A, Churchill ML, et al. Prenatal depression and risk of child autism-related traits among participants in the Environmental influences on Child Health Outcomes program[J]. Autism Res, 2023, 16(9):1825-1835. doi: 10.1002/aur.2988. pmid: 37526980
[28]	Han VX, Patel S, Jones HF, et al. Maternal acute and chronic inflamma-tion in pregnancy is associated with common neurodevelopmental disorders: a systematic review[J]. Transl Psychiatry, 2021, 11(1):71. doi: 10.1038/s41398-021-01198-w.
[29]	李辉. 儿童孤独症谱系障碍影响因素分析及预测模型构建[J]. 中国现代医生, 2024, 62(25):17-21. doi: 10.3969/j.issn.1673-9701.2024.25.004.
[30]	Girchenko P, Lahti-Pulkkinen M, Laivuori H, et al. Maternal Antenatal Depression Is Associated With Metabolic Alterations That Predict Birth Outcomes and Child Neurodevelopment and Mental Health[J]. Biol Psychiatry, 2025, 97(3):269-278. doi: 10.1016/j.biopsych.2024.07.023.
[31]	Qiang J, Wu D, Du H, et al. Review on Facial-Recognition-Based Applications in Disease Diagnosis[J]. Bioengineering(Basel), 2022, 9(7):273. doi: 10.3390/bioengineering9070273.