Abstract:

Vitamin D (VD) is one of the essential nutrients in pregnancy and perinatal period. It is not only related to bone metabolism, but also has multiple neural activities affecting neuroimmune regulation, neurotrophic factors and neurotransmission in the brain. Recent studies have found that VD has varying degrees of influence on the occurrence of depression. Prenatal and postnatal depression as a branch of depression, their relationship with VD is also being studied. VD deficiency can not only lead to recurrent spontaneous abortion, gestational diabetes and pre-eclampsia, but also be associated with depression symptoms during pregnancy and postpartum. It has been reported that VD deficiency may be one of the important risk factors for perinatal depression. Reasonable perinatal VD supplementation has a certain prevention and treatment effect on depression, but more studies are needed to confirm the timing and dose of VD supplementation. Combined with the domestic and foreign literatures published in recent years, we reviewed the correlation between VD deficiency and perinatal depression in this article, providing theoretical basis for early prevention, early diagnosis and timely treatment of the disease, and providing new ideas for later research.

Key words: Vitamin D, Depressive disorder, Depression, postpartum, Pregnancy, Therapy