Abstract: Functional hypothalamic amenorrhea（FHA） is a non-organic and reversible disorder which is due to the disorder of gonadotropin-releasing hormone（GnRH） pulsatile secretion. Nowadays, a lot of hormones of central nervous system are found to play an important role in the regulation of GnRH pulsatile secretion and thus be involved in the pathophysiology of functional hypothalamic amenorrhea. The purpose of this review is to update practitioners on the mechanisms of functional hypothalmaic amenorrhea and the related hormones in order to explore the new therapeutic strategy for FHA.

Key words: Hypothalamic amenorrhea, Leptin, Ghrelin, Corticotropin-releasing hormone, Neuropeptide Y, Peptide YY