Abstract: Tissue factor pathway inhibitor-2（TFPI-2） belongs to the Kunitz-type serine proteinase inhibitor family, and it is a broad-spectrum inhibitor of serine proteinase. A great number of studies show that, TFPI-2 can inhibit and degrade matrix metalloproteinase, inhibit the angiogenesis and the signal transduction pathway mediated by TF-FVIIa compound and induce apoptosis of tumor cells to accommodate the invasion and metastasis of some malignant tumor. In this article, we reviewed progress in research on the feature of molecular biological of TFPI-2, its relationship with the invasion and metastasis of malignant tumor, and with gynecological tumors.

Key words: Tissue factor pathway inhibitor-2, Matrix metalloproteinase, Invasion, Metastasis, Gynecologic neoplasm