Abstract: Phosphoglycerate dehydrogenase (3-PGDH or PHGDH) is the key enzyme of de novo serine biosynthesis. The PHGDH gene located in human chromosomes 1p12, which is highly expressed in normal tissue, especially for the nervous system function. Recently, it was shown that a part of intermediate metabolites of glycolysis flew to serine biosynthesis. It was found PHGDH gene amplification and over expression in some tumor, PHGDH regulated tumor cell proliferation, apoptosis and invasion. Cell metabolism of tumor is benefit to tumor oncogenesis and progression. The study found that silence PHGDH can inhibit tumor cell proliferation, invasion and increase cell apoptosis. And PHGDH may be a potential treatment target. In this paper, we will review briefly the studies on PHGDH, including structural features, biological function and the genesis and development effect in some tumor.

Key words: Neoplasms, Serine biosynthesis, Phosphoglycerate dehydrogenase