Abstract: Angiogenesis is important in the development and metastasis of tumors, which can meet requirement of organism metabolism and provide vascular access for distant metastasis, and considered to be closely related to prognosis. CD105 also named as Endoglin, which is a member of TGF-β super family receptors, has great specificity in marking tumor neovascularization. Recently, with the further researches in the function and mechanism of tumor cells and stromal cells, CD105 has increasingly application in diagnosis and prognostic evaluation for gynecological malignant tumors. Comprehensive understanding of biological characteristics of CD105 can provide a breakpoint of prevention, diagnosis and therapy for gynecological malignant tumors.

Key words: Transforming growth factor beta, Genital neoplasms，female, Receptors，transforming growth factor beta, CD105