Abstract: Female pelvic floor dysfunction (FPFD) is one of the most common chronic diseases affecting women′s health in our country, with primary clinical manifestations of pelvic organ prolapse (POP) and stress urinary incontinence (SUI). Currently, basic and clinical studies suggest that pelvic floor muscle damage and abnormal metabolism of protein in pelvic floor supportive tissue are the major pathogenesis of FPFD. On the one hand, pelvic floor muscle damage is mainly caused by pregnancy and menopause. On the other hand, the abnormal metabolism of collagen is associated with transforming growth factor β (TGF-β), decorin (DN), matrix metalloproteinases (MMPs) and their antagonists (TIMPs). Besides, lysyl oxidase (LOX) and Fubilin protein are relative to the abnormal metabolism of elastin. In this paper, related risk factors of pelvic floor muscle damage and factor regulation of pelvic floor supportive tissue are discussed, hoping to deepen the pathogenesis of female pelvic floor dysfunction and provide information for its clinical therapy.

Key words:  Female pelvic floor dysfunction, Pelvic floor muscle, Proteometabolism, Hormone, Pelvic floor, Prolapse, Urinary incontinence, stress, Muscle tonus