Abstract: Objective：To observe the influence of laparoscopic surgery and laparotomy on postoperative fatigue syndrome (POFS) and immunity function in early cervical cancer patients with hysterectomy. Methods：78 patients with early cervical cancer who were admitted from January 2014 to December 2015 in our hospital were divided into laparoscopic surgery group, 43 cases, and laparotomy group 35 cases. The general information of operation, fatigue score by Christensen evaluation method and immunity function before operation and postoperative 1 d, 3 d and 7 d were compared between the two groups. Results：The laparoscopic surgery time is longer than laparotomy, but intraoperative blood loss and postoperative hospital stay was significantly less than laparotomy group (P＜0.05). After operation, all the patients′ POFS score was higher than preoperative, and declined gradually over time, while the laparoscopic group improved more significantly than the laparotomy group (P＜0.05). The immune globulin level and T cell subgroup count declined significantly after operation, and the laparoscopic group declined less than the laparotomy group (P＜0.05), the recovery effect in laparoscopic group was better than laparotomy group (P＜0.05). Conclusions：The laparoscopic hysterectomy for early cervical cancer caused less trauma on patients and less immunity function inhibition, could reduced the POFS degree and improve the operation effect and promote clinical rehabilitation. It′s worthy of clinical popularization.

Key words: Uterine cervical neoplasms, Laparoscopes, Laparoscopy, Postoperative fatigue syndrome, Fatigue syndrome, chronic, Postoperative complications, Immunity