Abstract: Objective：We analyzed the umbilical blood gas and investigated its possible influencing factors in neonates of women with gestational diabetes mellitus (GDM). Methods：This study included 152 singleton pregnant women with GDM and 152 women with normal glucose tolerance (normal glucose tolerance, NGT) who delivered in Shanghai First Maternity and Infant Hospital from June to August 2015. Of 152 women with GDM, 69 were delivered vaginally, and 83 underwent cesarean delivery; and 11 required insulin therapy. Umbilical blood gases were measured. Results：The umbilical venous BE in the GDM group was lower than that in the NGT group (t=2.702，P=0.007). There were statistic differences in umbilical artery pH, umbilical venous pH, umbilical artery BE, umbilical venous BE and umbilical venous p(CO2), while neonatal outcomes showed no differences (P＞0.05), when compared with different delivery mode in women with GDM (P＜0.05). Insulin therapy showed no difference in umbilical blood gas analysis and outcomes (P＞0.05). Conclusions：The umbilical blood gas in neonates of women with GDM, who controls her blood glucose well, is similar to that of women with NGT. The mode of delivery and insulin therapy did not significantly affect neonatal-outcome.

Key words: Diabetes, gestational, Blood gas analysis, Fetal blood, Infant, newborn