Journal of International Obstetrics and Gynecology

Journal of International Obstetrics and Gynecology ›› 2016, Vol. 43 ›› Issue (1): 8-10.

• 综述 • Previous Articles     Next Articles

Research Progress of Matrix Metalloproteinases in Preterm Premature Rupture of Membranes through Degrading Extracellular Matrix

LI Wen, CHANG Ying, LI Xing, XU Ya-ling, CHEN Xu   

  1. Tianjin Central Hospital of Gynecology Obstetrics, Tianjin 300100, China（LI Wen，CHANG Ying，CHEN Xu）；Tianjin Medical University，Tianjin 300070，China（LI Xing，XU Ya-ling）
  • Received:1900-01-01 Revised:1900-01-01 Published:2016-02-15 Online:2016-02-15

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Abstract: Preterm birth is the first critical factor of life, threatening diseases for the perinatal. According to the statistics, the preterm birth rate in China reached 8.1% in 2012. And the frequency of preterm premature rupture of membranes（PPROM） is about 25%-30%, and intrauterine infection is the principal element. The recent research shows that a molecular mechanism of PPROM is advanced degradation of extracellular matrix, which due to the activation of matrix metalloproteinases（MMPs） in fetal membrane. The high expression of cytokines, such as IL-1, IL-6 and TNF-α, maybe the reason of MMPs′ activation. The process of activation and secretion of MMPs in term labor and preterm birth still need to be explored, which may be considered as a marker of pregnancy outcome. MMPs can provide a breakpoint of prevention and therapy for PPROM.

Key words: Matrix metalloproteinases, Infection, Cytokines, Premature birth, Fetal membranes, premature rupture