Research Progress on the Role of ATP Citrate Lyase in Recurrent Spontaneous Abortion

doi:10.12280/gjfckx.20250333

Abstract

Abstract:

Recurrent spontaneous abortion (RSA) is a complication of pregnancy, and its occurrence is related to many factors, such as abnormalities immune function, anatomical structure, chromosomal abnormalities, and endocrine abnormalities. Some targeted drugs have achieved certain curative effects in the treatment of RSA. Studies have shown that ATP citrate lyase (ACLY) can affect cell proliferation and function through intracellular metabolic pathways such as glucose metabolism and lipid metabolism. It can also mediate the expression of relevant cytokines through histone acetylation, thereby influencing the proliferation of immune cells and immune regulation, and participating in epigenetic regulation. This review summarizes the potential mechanism of action of ACLY in RSA, aiming to provide new theoretical basis for the targeted therapy of RSA.

Key words: ATP citrate (pro-S)-lyase, Abortion, habitual, Immunity, cellular, Cytokines, Cell metabolism

REN Xiang-ning, LI Ping. Research Progress on the Role of ATP Citrate Lyase in Recurrent Spontaneous Abortion[J]. Journal of International Obstetrics and Gynecology, 2025, 52(4): 384-388.

Figures/Tables 1

References 39

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细胞因子	作用细胞	发挥的作用	参考文献
IL-2，IFN-γ	Th1细胞	促炎	[20]
IL-4，IL-5， IL-6，IL-10	Th2细胞	抗炎	[20]
IL-17，IL-21， IL-22	Th17细胞	促炎	[22]
IGF-β，IL-10	Treg细胞	抗炎	[22]
IL-1β，IL-4， IL-6，IL-8， IL-10，IL-13， IFN-γ，TNF-α	子宫NK细胞	促炎/抗炎	[27,31 -32]
IL-10，TGF-β	蜕膜巨噬细胞	抗炎	[33]
IL-35	滋养细胞	免疫耐受	[34]
TNF-α，IL-1β	子宫内膜基质细胞	促炎	[35]
IL-6，IL-10	蜕膜基质细胞	抗炎	[19]

细胞因子	作用细胞	发挥的作用	参考文献
IL-2，IFN-γ	Th1细胞	促炎	[20]
IL-4，IL-5， IL-6，IL-10	Th2细胞	抗炎	[20]
IL-17，IL-21， IL-22	Th17细胞	促炎	[22]
IGF-β，IL-10	Treg细胞	抗炎	[22]
IL-1β，IL-4， IL-6，IL-8， IL-10，IL-13， IFN-γ，TNF-α	子宫NK细胞	促炎/抗炎	[27,31 -32]
IL-10，TGF-β	蜕膜巨噬细胞	抗炎	[33]
IL-35	滋养细胞	免疫耐受	[34]
TNF-α，IL-1β	子宫内膜基质细胞	促炎	[35]
IL-6，IL-10	蜕膜基质细胞	抗炎	[19]