The Role of NF-κB in the Pathogenesis of Endometriosis

doi:10.12280/gjfckx.20220257

Abstract

Abstract:

Endometriosis (EMs) is a common and frequently-occurring disease in gynecology. The pathogenesis of EMs is not fully understood, but it has been proved to be closely related to inflammatory responses, immune factors, endocrine and hormonal factors. Nuclear factor-κB (NF-κB) is a protein complex that plays an important role in DNA transcription, cytokine synthesis, apoptosis and differentiation. NF-κB expression is different in ectopic, in eutopic and normal endometrial cells. NF-κB plays an important role in inflammatory response, hormone synthesis, adhesion factor and angiogenesis factor, which are closely related to the occurrence and development of EMs. The possible role of NF-κB in the pathogenesis of EMs is reviewed in order to provide new ideas and methods for the treatment of EMs.

Key words: NF-kappa B, Endometriosis, Cytokines, Inflammation, Estrogens, Progestins, Cell adhesion, Vascular endothelial growth factors

WANG Song, ZHANG Wei, SONG Dian-rong. The Role of NF-κB in the Pathogenesis of Endometriosis[J]. Journal of International Obstetrics and Gynecology, 2022, 49(4): 461-465.

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