Abstract: Uterine serous carcinoma(also known as Uterine papillary serous carcinoma ,UPSC ), is a main kind of estrogen-independent type Ⅱ uterine endometrial cancer. It is highly aggressive with high invasive ability, high recurrence rate after surgery. And the recurrent UPSC is often multifocal and the carcinoma is located outside the pelvic in most cases, leading to difficult situation which can′t be fixed with traditional treatment such as surgery or radiotherapy. Due to the low incidence rate of UPSC, previous study with limited cases can′t accomplish the classification and detailed statistical analysis. The present review lists recent articles with retrospective analysis of big data cases and introduces the clinical characteristics of UPSC with reference to treatment recommendation of the American Society of Gynecologic Oncology (SGO) and American National Comprehensive Cancer Network (NCCN), offering data support for various therapy choices for different FIGO stage patients. The present review also aims to improve the cognition of UPSC and help gynecologists to master the treatment principle of this disease.

Key words: Endometrial neoplasms, Neoplasms, cystic, mucinous, and serous, Diagnosis, Gynecologic surgical procedures, Antineoplastic combined chemotherapy protocols, Radiotherapy