Abstract: Objective：To investigate the effects of Penyanqing suppository combined with cefaclor on serum monocyte chemotactic protein-1 (MCP-1) and T cell subsets in patients with chronic pelvic inflammation. Methods: 110 patients with chronic pelvic inflammatory disease, who were diagnosed and treated in our hospital from January 2016 to August 2017, were randomly divided into observation group and control group with 55 cases in each group. The control group was treated with cefaclor, while the observation group received penyanqing suppository combined with cefaclor. After 2 courses of treatment, the curative effect, hemorheology, uterine artery blood flow, serum MCP-1 and T lymphocyte subsets were observed in the two groups. Results: The total effective rate of observation group was 92.73%, which was significantly higher than that of the control group (74.55%) (P＜0.05). There were no significant differences in hemorheology, uterine artery perfusion index (PI), resistance index (RI), serum MCP-1 and T cell subsets between the two groups before treatment (P＞0.05). After treatment, hematocrit, platelet aggregation rate, blood viscosity, fibrinogen, uterine artery blood flow PI in two groups were significantly decreased,  observation group decreased significantly compared with the control group, the difference was significant (P＜0.05). After treatment, the MCP-1 of the two groups decreased significantly, and observation group was lower than control group, and the difference was statistically significant (P＜0.05). After treatment, the CD4+ of the two groups increased, the observation group increased more than control group, the CD8+ of the two groups decreased, the observation group decreased significantly, the CD4+/CD8+ level of the observation group was  higher than  control group, the difference was significant (P＜0.05). Conclusions: Penyanqing suppository combined with cefaclor is effective in treating chronic pelvic inflammatory disease. It can improve hemorheology effectively, reduce the level of serum MCP-1, T lymphocyte subsets, which can be widely used in clinic.

Key words:  Penyanqing suppository, Cefaclor, Chronic pelvic inflammatory disease, Serum MCP-1, T lymphocyte subsets