Abstract: Objective：To investigate oxidative stress injury levels in serum and placenta of pre-eclampsia（PE） in pregnant women complicated with organ involvement. Methods： 30 PE patients complicated with organ involvement who were admitted to Fujian Medical University Union Hospital for delivery from December 2012 to December 2014 were chosen as study group, 30 patients without organ involvement were chosen as control group one, another 30 normal pregnant women at the same time were chose as control group two. Ultraviolet colorimetry was used to detect glutathione peroxidase（GPX） and catalase（CAT） activity in maternal serum and placenta, as well as the malondialdehyde（MDA） level. WST was used to detect superoxide dismutase（SOD） activity in serum and placenta. Results：①Mean maternal serum and placenta GPX，CAT and SOD activity were significantly decreased in the study group and control group one as compared to control group two, study group were also lower than the control group one, both of the difference had statistical significance（P＜0.05）. ②Mean maternal serum and placenta MDA were significantly elevated in the study group and control group one as compared to control group two, and the study group were also higher than the control group one, both of the difference had statistical significance（P＜0.05）. ③Mean maternal serum and placenta MDA concentration were negatively correlated with the levels of GPX，CAT and SOD in study and control group one（P＜0.05）. No obvious correlation was found in the control group two. Conclusions：Serum and placenta enhanced oxidative stress damage may be an important factor in the onset of PE, and can lead to PE women concurrent organ involvement. Antioxidant enzyme activity in serum and placental tissue levels drop may be the cause of the elevated levels of serum and placenta oxidative stress injury.

Key words: Pre-eclampsia, Pregnancy complications, Oxidative stress, Glutathione, Catalase, Superoxide dismutase