Abstract: This article analyzes the clinical data of a case of recurrent venous thrombosis of the lower extremity with familial thrombosis in pregnancy admitted to the Second Hospital of Jilin University and retrospectively analyzes the relevant literatures as well as data in the past. The risk of venous thromboembolism (VTE) of lower extremity in pregnant women is about 5 times higher than that in non-pregnant women. The history of VTE in pregnant women and family history of VTE in pregnant women are the high risk factors of VTE. This patient had a recurrence after thrombolytic therapy for venous thrombosis in the lower extremity during the puerperium. No adverse effects were observed after this anticoagulant therapy. For VTE high-risk pregnant and lying-in women, appropriate anticoagulant therapy has more advantages than disadvantages, especially in puerperium. Moreover, the increased rate of cesarean section increases the risk of postoperative VTE. Therefore, prenatal evaluation, close observation after delivery and appropriate anticoagulation therapy can reduce the recurrence rate of pregnancy-related VTE.

Key words: Venous thrombosis, Pregnancy complications, Recurrence, Anticoagulants, Case reports