Abstract: With the liberalization of the second-child policy, the number of elderly mothers is increasing, thus the age of pregnant women is increasing, and the incidence of internal and surgical disease is also increasing, which also leads to an increase in the adverse outcomes of older pregnant women and perinatal children. Before the implementation of the "two-child policy", the rate of cesarean section in many hospitals in China was much higher than the 15% level recommended by the World Health Organization. With the "two-child policy" landing, the elderly women who originally chose cesarean section once again gave birth to new life. With the increase of age, the body functions of women of childbearing age gradually declines, and reproductive system function also gradually declines, while scar uterus gradually become aging and its contraction ability declines. How to ensure the safe delivery of elderly women with scarred uterus and a variety of internal and surgical diseases is a new difficult problem for obstetricians. By consulting relevant literatures and summarizing the cases of advanced pregnancy with cerebral aneurysm, carotid aneurysms, intrahepatic cholestasis of pregnancy, and gestational diabetes in Qinghai University Affiliated Hospital, this article deepen obstetricians′ attention and understanding of related diseases.

Key words: Pregnant women, Pregnancy complications, Cholestasis, intrahepatic, Diabetes, gestational, Intracranial aneurysm；Carotid artery diseases