Abstract: Objective：To explore the suitable method of induced labor in the condition of placenta previa during middle pregnancy. Methods：Retrospective analysis of 89 cases of placenta previa patients induced abortion in Department of Obstetrics of Henan Provincial People′s Hospital. Group A was induced by Mifepristone combined with Ethacridine (64 cases), which received oral mifepristone 50 mg twice a day for 5 days and followed by amniocentesis administration of Ethacridine 100 mg under the guidance of color doppler ultrasound on the 5th day afternoon. Group B was treated with abdominal hysterotomy (25 cases). The general situation, induction of labor and repregnancy of the 2 groups were compared. Results：The amount of bleeding and hospitalization cost in group A were significantly lower than those in group B, and the difference was statistically significant (P＜0.05). The success rate of induced labor in patients with incomplete placenta previa and complete placenta previa were 96.3% (52/54) and 70% (7/10), respectively. The rate of cesarean section of the former is significantly lower than that of the latter (P=0.024). When re-pregnancy, the probability of abnormal placenta in group A was significantly lower than that in group B, and the difference was statistically significant (P=0.014). Conclusions：For patients with placenta previa in the second trimester, induction of labor by amniocentesis after oral administration of Mifepristone can reduce the amount of bleeding during labor, reduce the cost of hospitalization, and reduce the injury of parturient by abdominal hysterotomy. It can reduce the probability of placental abnormity in the second pregnancy and can be used as one of the clinical choices.

Key words: Placenta previa, Pregnancy trimester, second, Labor, induced, Mifepristone