Abstract: Objective：To analyze the occurrence and influencing factors of postpartum cognitive dysfunction in active labor analgesia and non-labor analgesia. Methods: The 217 women with vaginal delivery in our hospital from January 2016 to December 2018 were selected as the research objects. According to the principle of voluntary selection, the women were divided into the labor analgesia group (82 cases) and the non-labor analgesia group (135 cases). The pain scores at different stages of labor and the incidences of cognitive dysfunction on the first and 42nd day of postpartum were compared between the two groups, and the influencing factors were analyzed. Results: The visual analogue score(VAS) score at 6 cm and 10 cm of uterine in the labor analgesia group were significantly lower than those in the non-labor analgesia group (P＜0.001), and there was no statistical difference in the VAS score at 3 cm in labor analgesia group (P＞0.05). The scores of the Montreal cognitive assessment(MoCA) and the symbol digit modalities test(SDMT90) in the labor analgesia group were significantly higher on the first day of postpartum, and the incidence of cognitive dysfunction was lower than those in the non-labor analgesia group (P＜0.05). There were no significant differences in the scores of MoCA and SDMT90 and the incidence of cognitive dysfunction between the two groups on the 42nd day of postpartum (P＞0.05). Non-labor analgesia and VAS score＞5 at 3 cm, 6 cm and 10 cm of uterine opening were the influence factors of cognitive dysfunction on the first day of postpartum (P＜0.05). Age ≥35 years and graduated from high school and below were not correlated with cognitive dysfunction on the first day of postpartum (P＞0.05). Conclusions: Labor analgesia can reduce the risk of postpartum cognitive dysfunction on the first day of postpartum by effectively relieving labor pain while non-labor analgesia and labor pain are independent risk factors of postpartum cognitive dysfunction.

Key words: Analgesia, obstetrical, Labor, obstetric, Cognition, Pain