Abstract: Objective：To explore the role of cervical cytology and human papillomavirus (HPV) screening of cervical precancerous disease in postmenopausal women. Methods：113 postmenopausal cases who underwent colposcopic biopsy due to screening abnormality were performed in a retrospective analysis from October 2017 to September 2018. The detection of cervical lesions by different TCT and HPV results was analyzed. The sensitivity, specificity, PPV and NPV of TCT and HPV detection in high squamous intraepithelial lesions (HSIL) were compared. Results：There was no significant difference between the distribution of high-risk HPV (HR-HPV) infection and cervical lesions in postmenopausal women ( χ2=0.809, P=0.303). It had statistically significance that those with high-risk in cytology or positive results in immunohistochemistry had severer cervical diseases than the counterparts( χ2=29.018, P=0.000; r=0.389, P=0.000). Sensitivity, specificity, PPV and NPV of TCT and HR-HPV testing in postmenopausal women were separately 78.38%, 75.00%, 60.42%, 87.69% and 94.59%, 10.13%, 33.98%, 80.00%. Conclusions: Postmenopausal women with high TCT level and positive immunohistochemistry have the risk of high-level cervical lesions, which should be paid attention to by clinicians.

Key words: Menopause, Uterine cervical neoplasms, Precancerous conditions, Immunohistochemistry, Papillomaviridae