Abstract: Pre-eclampsia is a pregnancy-specific disease and a leading cause of maternal and perinatal death. Until now, no hypothesis can fully explain the pathological changes of pre-eclampsia, which is characterized by early placental trophoblast infiltration and decreased spiral artery remodeling. ACVR2A (activin A receptor type 2A), a member of the transforming growth factor β (TGF-β) receptor family, is considered as an important regulator of reproductive function, especially in the process of decidualization, trophoblast cell infiltration and placental formation. Recent studies have shown that activin A and its receptor play an important regulatory role in the occurrence and development of pre-eclampsia. This paper reviews the relationship between ACVR2A and pre-eclampsia, aiming to provide a new theoretical basis for the pathogenesis, early diagnosis and treatment of pre-eclampsia.

Key words: Pre-eclampsia;, ACVR2A, Trophoblast invasion, Trophoblasts;, Spiral artery remodeling