Connexin 43 and Premature Rupture of Membranes Related Problems

doi:10.12280/gjfckx.20200558

Abstract

Abstract:

Premature rupture of membranes (PROM) is one of the most common causes of preterm delivery in obstetrics, which can induce poor prognosis, such as neonatal respiratory distress syndrome, chorioamnionitis, placental abruption, septicemia and so on. Gap junction communication is the most common way of information exchange and material exchange between cells. Its function is mainly realized by gap junction proteins. Connexin43 (Cx43) is the most common and important protein in the gap junction family, Cx43 can connect cells to form a complete transmission channel between cells, which plays an important role in intercellular gap junction, the exchange of information and materials between cells, and fetal membrane integrity. It is closely related to the levels of type I and III collagen in fetal membranes, which can cause weakening of the fetal membranes by affecting the amount of type I and III collagen and the cross-linking method, lead to premature rupture of the fetal membranes. The decrease of Cx43 can lead to the occurrence and expansion of fetal membrane microfissures and lead to premature rupture of fetal membranes. This article reviews the correlation between Cx43 and premature rupture of membranes in order to have a better understanding of the mechanism, prevention and treatment of premature rupture of membranes.

Key words: Gap junctions, Connexins, Connexin 43, Fetal membranes,premature rupture, Premature birth, Collagen, Microcracks

NAN Lian-ling, MU Wan-ru, ZHANG Hong, LI Jie, YANG Chen-chen, TANG Ling, BAI Yu-fang. Connexin 43 and Premature Rupture of Membranes Related Problems[J]. Journal of International Obstetrics and Gynecology, 2021, 48(1): 79-83.

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