Research Progress of NLRP3 Inflammasome and Pregnancy

doi:10.12280/gjfckx.20200965

Abstract

Abstract:

Inflammasome are an important part of the natural immune system and participate in many inflammatory reactions including pregnancy. NLRP3 inflammasome is the most widely studied inflammasome, which is an important factor of host defense response. It can regulate innate immunity, various environmental stimuli, various microorganisms, endogenous or exogenous danger signals, pathogens and different PAMPs/DAMPs can activate NLRP3 inflammasome to release cytokines,induce caspase-1 dependent apoptotic process,and participate in various inflammatory disease processes, but the regulatory mechanism is not clear. In recent years, it has been found that NLRP3 inflammasome is associated with the mechanism of delivery, and the NLRP3-mediated immune response is initiated during pregnancy. The abnormal expression of NLRP3 inflammasome is associated with the development of gestational diseases such as recurrent miscarriage, premature birth, preeclampsia and gestational diabetes. This article reviews the research progress of NLRP3 inflammasome and pregnancy.

Key words: NLR family,pyrin domain-containing 3 protein, Inflammasomes, Parturition, Pregnancy, Diabetes,gestational, Pre-eclampsia, Premature birth, Abortion,habitual

ZHAO Lu, YANG Hua, LIU Guo-yan. Research Progress of NLRP3 Inflammasome and Pregnancy[J]. Journal of International Obstetrics and Gynecology, 2021, 48(3): 255-258.

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