Research Progress of PD-L1, B7-H3 and B7-H4 in Immunotherapy of Cervical Cance

doi:10.12280/gjfckx.20201027

Abstract

Abstract:

Cervical cancer is a common gynecological malignancies in China. Its occurrence and development are often related to immune escape. Immunotherapy has become a research hotspot in the treatment of cervical cancer. With the successful application of immune checkpoint programmed death 1 ligand (PD-L1) and programmed death 1 (PD-1) inhibitors in a variety of malignant tumors, the study of costimulatory factors represented by PD-L1 and cervical cancer has attracted more and more attention, among which negative costimulatory factors are closely related to the immunosuppression of cervical cancer. PD-L1, namely B7-H1, is a common negative costimulatory factor along with B7-H3 and B7-H4, which causes immune escape of cancer cells by inhibiting the immune response. Many studies have shown that PD-L1, B7-H3 and B7-H4 are abnormally high expressed in cervical cancer, which inhibits the immune response to cervical cancer cells, and has corresponding clinical significance in the development, invasion, metastasis and prognosis of cervical cancer. This paper reviewed the biological functions of negative costimulatory factors PD-L1, B7-H3 and B7-H4, as well as their expression and application in cervical cancer, in order to provide a new idea for the immunotargeted therapy of cervical cancer.

Key words: Co-stimulator, Uterine cervical neoplasms, PD-L1, B7-H3, B7-H4, Immunotherapy

SU Ya-ting, LYU Jie, NIU Wen-juan, WEI Fang. Research Progress of PD-L1, B7-H3 and B7-H4 in Immunotherapy of Cervical Cance[J]. Journal of International Obstetrics and Gynecology, 2021, 48(4): 457-461.

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