The Relationship between Lipid Alterations during Pregnancy and Gestational Diabetes Mellitus

doi:10.12280/gjfckx.20210266

Abstract

Abstract:

Due to the changes of estrogen and progesterone level during pregnancy, the endocrine metabolism will undergo corresponding physiological changes during pregnancy. But when the changes exceed the physiological upper limit, it will cause a series of pregnancy complications, such as gestational diabetes mellitus (GDM), hypertensive disorder complicating pregnancy, premature rupture of membranes, preterm delivery and giant babies. GDM is one of the more common complications, and as an endocrine disease, GDM is often associated with abnormalities in glucose and lipid metabolism. However, abnormalities in lipid metabolism can also increase the risk of developing GDM. The detection and control of dyslipidemia in early pregnancy is of great significance for the prevention, confirmation and treatment of GDM, and therefore the study of lipid metabolism in GDM is of great interest. There are no clear findings on whether alterations in lipid metabolism increase the risk of developing GDM or whether the onset of GDM leads to disturbances in lipid metabolism. This paper will review the progress of research on normal lipid metabolism in pregnancy and the relationship between lipid metabolism and GDM in pregnancy.

Key words: Pregnancy, Diabetes,gestational, Insulin resistance, Dyslipidemias, Hyperlipidemias

LI Tian-tian, YUAN Jing. The Relationship between Lipid Alterations during Pregnancy and Gestational Diabetes Mellitus[J]. Journal of International Obstetrics and Gynecology, 2021, 48(6): 656-659.

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