Abstract:

Preeclampsia(PE) constitutes a prevailing maternal complication that is intricately bound up with adverse maternal and infant outcomes. As one of the important risk factors for the development of PE, the pathogenetic mechanism of twin pregnancy in conjunction with PE is comparable to that of singleton pregnancies, which could potentially be correlated with large placenta size, augmented volume load, vascular endothelial dysfunction, oxidative stress, and immune mechanisms, etc., manifesting early disease onset yet mild disease attributes. However, the mechanism of PE in twin pregnancy remains nebulous, and its specific risk factors embrace assisted reproductive technology and chorionic sex. Clinically, twin pregnancies accompanied by PE hinge upon a solitary predictor, such as soluble fms-like tyrosine kinase-1(sFlt-1), placental growth factor (PlGF), pregnancy associated plasma protein-A (PAPP-A), or ultrasound indicators. Due to shortcomings such as insufficient sample size, the predictive performance of each indicator still needs to be tested. Further research with larger sample sizes is needed to explore the optimal predictive model for twin pregnancies with PE, in order to guide clinical decision-making.

Key words: Pre-eclampsia, Pregnancy, twin, Pathogenesis, Forecasting, Clinical decision-making