The Role of SOCS1 and Exosomal MicroRNA in the Pathogenesis of Preeclampsia

doi:10.12280/gjfckx.20240757

Abstract

Abstract:

Preeclampsia (PE) is a serious complication of pregnancy whose main symptoms include hypertension and multi-system organ damage, which seriously affects the health of mother and child. Termination of pregnancy is currently the preferred treatment choice for PE. Although the pathogenesis of PE has not been completely clarified, recent studies have shown that exosomes from different sources and the microRNAs (miRNAs) they carry play key roles in the development of PE, especially miRNAs, as the most representative type of exosomal small RNAs, can be involved in the pathophysiological process of PE through the regulation of trophoblast function and signaling pathways. In particular, exosomes miRNAs can inhibit suppressor of cytokine signaling 1 (SOCS1), thereby regulating the maternal immune responses. In addition, exosomal miRNAs show potential in the early diagnosis of PE and are expected to be biomarkers for the prediction of PE.

Key words: Exosomes, MicroRNAs, Exosomal small RNA, Pre-eclampsia, Suppressor of cytokine signaling 1 protein, Pathogenesis

ZHANG Wen, LIU Hui-qiang. The Role of SOCS1 and Exosomal MicroRNA in the Pathogenesis of Preeclampsia[J]. Journal of International Obstetrics and Gynecology, 2025, 52(1): 94-98.

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