Confused Problem of Magnesium Sulfate in the Treatment of Preeclampsia and Its Adverse Effects

doi:10.12280/gjfckx.20240157

Abstract

Abstract:

Preeclampsia is an idiopathic disease during pregnancy that leads to adverse pregnancy outcomes for both mothers and children. Spasmolysis is an important and effective means to treat preeclampsia, and magnesium sulfate is the first-line spasmodic drug. At present, there are still some controversies about magnesium sulfate in the treatment of preeclampsia, including：whether magnesium sulfate is used for non-severe preeclampsia, magnesium sulfate is not recommended to prevent seizures in previous studies. However, recent studies believe that magnesium sulfate should be used to prevent eclampsia in patients with preeclampsia. Regarding the question of the course of prenatal magnesium sulfate for preeclampsia, several studies in recent years have concluded that the course of magnesium sulfate should be less than 24 h. Postpartum magnesium sulfate can prevent seizures, and existing studies support that postpartum magnesium sulfate application can be less than 24 h or even not used. Adverse reactions associated with the use of magnesium sulfate, including increased maternal postpartum haemorrhage risk, maternal hypermagnesemia, hypocalcemia, neonatal hypocalcemia and bone calcium deposition, neonatal hyperkalemia, etc.

Key words: Magnesium sulfate, Pre-eclampsia, Eclampsia, Drug-related side effects and adverse reactions, Hypermagnesemia, Therapy

ZHAO Li-xia, WANG Xiao-qing. Confused Problem of Magnesium Sulfate in the Treatment of Preeclampsia and Its Adverse Effects[J]. Journal of International Obstetrics and Gynecology, 2024, 51(4): 448-452.

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