Clinical Application and Modern Pharmacological Progress of Traditional Chinese Medicine in Preeclampsia

doi:10.12280/gjfckx.20240382

Abstract

Abstract:

Preeclampsia is a pregnancy-related disease clinically characterized by high blood pressure and proteinuria after 20 weeks of gestation. Preeclampsia is a serious danger to the life and health of mothers and infants, and is one of the main causes of maternal and perinatal mortality. For the past few years, multiple Chinese herbal formulas and Chinese medicine injections have been shown to prevent and treat preeclampsia, and good clinical efficacy has been achieved. Modern pharmacological studies have found that Puerarin, Gastrodin, Rhynchophylline, Ginsenoside, Atractylenolide, Danshensu, Tetramethylpyrazine, Astragaloside can promote trophoblast proliferation and invasion, improve the process of pregnancy in experimental animals and play a positive role in the treatment of preeclampsia. Through the relevant literature and analysed the rationality of the clinical use of traditional Chinese medicines by combining clinical efficacy and mechanism studies, this research aims to accelerate and promote the clinical application and development of traditional Chinese medicine in the prevention and treatment of preeclampsia.

Key words: Pre-eclampsia, Trophoblastic cell, Treatment outcome, Traditional Chinese drugs, Pharmacology

REN Yi, HU Yu-lian, WANG Xin, ZHANG Qi, LIU Chao, GAO Hui-jie. Clinical Application and Modern Pharmacological Progress of Traditional Chinese Medicine in Preeclampsia[J]. Journal of International Obstetrics and Gynecology, 2024, 51(4): 442-447.

Figures/Tables 1

References 40

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方剂/中成药/注射液	相似方剂（成分）	文献报道（近10年）	适用诊断	疗效评价（对比对照组患者）
葛根汤	黄芪党参葛根汤	5篇	PE；ESPE；妊娠期高血压	尿蛋白、动脉压、脐动脉血流阻力降低显著，孕周延长，抑制氧化应激
天麻钩藤饮	天麻钩藤饮加减；天麻钩藤饮加味；半夏白术天麻汤	9篇	PE；SPE；ESPE；妊娠期高血压	降血压、降尿蛋白效果显著，症状改善，内皮功能恢复明显，凝血功能改善，肾功能恢复明显
四君子汤	黄芪四君子汤	5篇	妊娠期高血压	治疗总有效率高，预后良好
丹参滴丸	复方丹参滴丸	5篇	PE；SPE；ESPE	降低凝血程度，改善妊娠结局
丹参注射液	复方丹参注射液；香丹注射液	105篇	PE；SPE；ESPE；妊娠期高血压	降血压，调节微循环，改善凝血功能，减少并发症，降低妊娠不良结局发生率，胎龄延长，新生儿死亡率降低，产后出血减少
川芎嗪注射液	无	10篇	PE；SPE；ESPE；妊娠期高血压	降血压，并发症发生率及新生儿死亡率显著降低
丹参川芎嗪注射液	丹参注射液联合川芎嗪注射液	5篇	PE；SPE；ESPE	降血压，抑制炎症及氧化损伤，保护血管内皮功能，症状减轻，妊娠结局改善
黄芪注射液	无	3篇	PE	凝血功能改善，产后出血减少

方剂/中成药/注射液	相似方剂（成分）	文献报道（近10年）	适用诊断	疗效评价（对比对照组患者）
葛根汤	黄芪党参葛根汤	5篇	PE；ESPE；妊娠期高血压	尿蛋白、动脉压、脐动脉血流阻力降低显著，孕周延长，抑制氧化应激
天麻钩藤饮	天麻钩藤饮加减；天麻钩藤饮加味；半夏白术天麻汤	9篇	PE；SPE；ESPE；妊娠期高血压	降血压、降尿蛋白效果显著，症状改善，内皮功能恢复明显，凝血功能改善，肾功能恢复明显
四君子汤	黄芪四君子汤	5篇	妊娠期高血压	治疗总有效率高，预后良好
丹参滴丸	复方丹参滴丸	5篇	PE；SPE；ESPE	降低凝血程度，改善妊娠结局
丹参注射液	复方丹参注射液；香丹注射液	105篇	PE；SPE；ESPE；妊娠期高血压	降血压，调节微循环，改善凝血功能，减少并发症，降低妊娠不良结局发生率，胎龄延长，新生儿死亡率降低，产后出血减少
川芎嗪注射液	无	10篇	PE；SPE；ESPE；妊娠期高血压	降血压，并发症发生率及新生儿死亡率显著降低
丹参川芎嗪注射液	丹参注射液联合川芎嗪注射液	5篇	PE；SPE；ESPE	降血压，抑制炎症及氧化损伤，保护血管内皮功能，症状减轻，妊娠结局改善
黄芪注射液	无	3篇	PE	凝血功能改善，产后出血减少