Regulation Mechanism of Hypothalamic Inflammation in Polycystic Ovary Syndrome

doi:10.12280/gjfckx.20220804

Abstract

Abstract:

Polycystic ovary syndrome (PCOS) is a common gynecological disease among women of reproductive age. It causes reproductive disorders and metabolic abnormalities, which has heterogeneous clinical manifestations. Hypothalamic inflammation is a low-grade inflammatory disease with microglial activation as the main pathological change, which is considered as the pathological and physiological basis of PCOS metabolism, reproduction and clinical heterogeneity. Recent researches have clarified the crucial role of the hypothalamus in regulating and maintaining metabolic homeostasis and reproductive function. Through the induction pathway of hypothalamic inflammation, it is proposed that the common excessive intake of carbohydrates and saturated fatty acids is the main inducement. Furthermore, the important role of hypothalamic inflammation in the occurrence and development of PCOS related metabolic and reproductive disorders and the potential inducing pathways were described, and the abnormal signal transduction among hypothalamic neurons and between the center and periphery were considered as the key pathways to induce PCOS related pathological changes. These pathways are expected to provide new ideas and targets for clinical treatment of PCOS.

Key words: Polycystic ovary syndrome, Hypothalamo-hypophyseal system, Inflammation, Metabolism, Insulin resistance

SUN Chang, PAN Zi-meng, ZHAO Shan-shan, LI Jing, KUANG Hong-ying. Regulation Mechanism of Hypothalamic Inflammation in Polycystic Ovary Syndrome[J]. Journal of International Obstetrics and Gynecology, 2023, 50(1): 109-115.

Figures/Tables 1

References 48

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