Ferroptosis-Related Mechanisms in Endometrial Cancer

doi:10.12280/gjfckx.20220736

Abstract

Abstract:

As one of the three female reproductive malignant tumors, endometrial cancer seriously endangers women′s health. Recent studies have revealed that ferroptosis is a critical factor in the initiation and progression of endometrial cancer. As a form of programmed cell death, Ferroptosis is closely related to multiple biological processes, such as iron metabolism, lipid metabolism and oxidative stress. It has been found that manipulation of iron metabolism and oxidative stress in endometrial cancer cells could lead to cancer cell ferroptosis and thus inhibit tumorigenesis. Additionally, regulation of ferroptosis-related pathway alters chemosensitivity of endometrial cancer patients, and comparative analysis of ferroptosis-related genes can be used for the prognosis prediction of endometrial cancer patients. Therefore, ferroptosis-related pathway proteins are promising targets for endometrial cancer treatment. This review briefly summarizes ferroptosis mechanisms and its role in the occurrence and treatment of endometrial cancer, and analyzes the potential application value of ferroptosis related molecules as a new type of molecular typing to predict the prognosis of endometrial cancer, and provides new ideas for the application of ferroptosis in the treatment of endometrial cancer.

Key words: Ferroptosis, Endometrial neoplasms, Iron, Oxidative stress, Prognosis, Therapy

WEI Yun-fang, WANG Xi-peng. Ferroptosis-Related Mechanisms in Endometrial Cancer[J]. Journal of International Obstetrics and Gynecology, 2023, 50(1): 11-15.

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