Reseach Progress of Cancer-Associated Fibroblasts in Endometrial Cancer

doi:10.12280/gjfckx.20220617

Abstract

Abstract:

The interaction of different types of cells in the tumor microenvironment(TME) plays a key role in the development of endometrial cancer. Among them, cancer-associated fibroblasts (CAFs), as an important component of TME, regulate the malignant bilolgical behavior of endometrial cancer through direct or indirect ways, and promote tumor progression. Studies have shown that CAFs are involved in regulating the pathways of proliferation, migration, invasion and metabolism of endometrial cancer cells, and they also play an important role in the matrix remodeling, angiogenesis and immune regulation of TME. Clinical trials targeting CAFs have broken the limitations of traditional treatments for endometrial cancer and brought new treatment options for patients with end-stage endometrial cancer, but only some patients will benefit. The sources and functional heterogeneity of CAFs are closely related to treatment resistance. This article reviews the research progress of CAFs in endometrial cancer to deeply understand the characteristics and functions of CAFs, so as to provide new ideas for the treatment of endometrial cancer.

Key words: Endometrial neoplasms, Cancer-associated fibroblasts, Tumor microenvironment, Neovascularization, pathologic, Therapy

YU Zhi-cheng, WANG Hong-bo. Reseach Progress of Cancer-Associated Fibroblasts in Endometrial Cancer[J]. Journal of International Obstetrics and Gynecology, 2023, 50(1): 16-19.

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