Clinical Application of Indocyanine Green Tracing of Sentinel Lymph Nodes in Early Cervical Cancer

doi:10.12280/gjfckx.20250018

Abstract

Abstract:

Cervical cancer is one of the malignant tumors that threaten women′s health. The traditional surgical approach typically involves systemic lymph node dissection, which may lead to increased postoperative complications and affect the quality of life of patients. Sentinel lymph node biopsy (SLNB) technology aims to assess the lymph node metastasis status of patients and reduce unnecessary lymph node dissection for some patients with negative sentinel lymph node (SLN), thereby reducing surgical trauma. Indocyanine green (ICG), as a fluorescent tracer, has shown high sensitivity and specificity in SLNB for early cervical cancer, with a detection rate superior to that of biological dyes, carbon nanoparticles, and radioactive isotopes. It is currently one of the most commonly used tracers. Due to its limited tissue penetration, further research should focus on the clinical transformation of ICG combined with carrier technology to overcome the limitations of existing techniques. This article aims to provide a comprehensive review of the application of ICG-traced SLN in early cervical cancer, providing a reference to promote the clinical application of SLNB technology.

Key words: Sentinel lymph node, Sentinel lymph node biopsy, Indocyanine green, Uterine cervical neoplasms, Tracer

CHAI Ling-na, LI Yan-li, SHI Jie, GAO Han, OUYANG Xi-yan, CHENG Shi-yu. Clinical Application of Indocyanine Green Tracing of Sentinel Lymph Nodes in Early Cervical Cancer[J]. Journal of International Obstetrics and Gynecology, 2025, 52(2): 175-179.

Figures/Tables 1

References 40

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示踪剂	优点	缺点
蓝色染料	成本低；安全性高；不需要高昂的显影设备	容易弥散至周围组织导致手术视野不清晰；显影不持久
纳米碳悬液	具有淋巴管趋向性；不需要显影设备；显影持久；安全性高	无穿透性，对于深部SLN观察不利；目前国内外相关研究较少
放射性核素	高敏感度；较高准确性；不易引流至下一站淋巴结	具有放射性；不易获取；成本高昂；需要特殊设备保存；操作不易
ICG	成本低；检出率高；实时观察淋巴动态循环；安全性高；使用方式简单；敏感度和特异度高	需要高昂显像设备；有一定的假阴性率；淋巴显影具有局限性；存在血管、淋巴管外渗可能，往往渗透至下一站淋巴结

示踪剂	优点	缺点
蓝色染料	成本低；安全性高；不需要高昂的显影设备	容易弥散至周围组织导致手术视野不清晰；显影不持久
纳米碳悬液	具有淋巴管趋向性；不需要显影设备；显影持久；安全性高	无穿透性，对于深部SLN观察不利；目前国内外相关研究较少
放射性核素	高敏感度；较高准确性；不易引流至下一站淋巴结	具有放射性；不易获取；成本高昂；需要特殊设备保存；操作不易
ICG	成本低；检出率高；实时观察淋巴动态循环；安全性高；使用方式简单；敏感度和特异度高	需要高昂显像设备；有一定的假阴性率；淋巴显影具有局限性；存在血管、淋巴管外渗可能，往往渗透至下一站淋巴结